diff --git a/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-sse41.c b/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-sse41.c
index b4c49f0e..a039b206 100644
--- a/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-sse41.c
+++ b/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-sse41.c
@@ -5,7 +5,8 @@
 #include <stdint.h>
 #include <string.h>
 
-#if defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H) && defined(HAVE_SMMINTRIN_H)
+#if (defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H) && defined(HAVE_SMMINTRIN_H)) && \
+    (defined(_MSC_VER) && (defined(_M_X64) || defined(_M_AMD64) || defined(_M_IX86)))
 
 #pragma GCC target("sse2")
 #pragma GCC target("ssse3")
diff --git a/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-ssse3.c b/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-ssse3.c
index 31043b18..a10f5c7e 100644
--- a/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-ssse3.c
+++ b/src/libsodium/crypto_generichash/blake2/ref/blake2b-compress-ssse3.c
@@ -4,7 +4,8 @@
 #include <stdint.h>
 #include <string.h>
 
-#if defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H)
+#if (defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H)) || \
+    (defined(_MSC_VER) && (defined(_M_X64) || defined(_M_AMD64) || defined(_M_IX86)))
 
 #pragma GCC target("sse2")
 #pragma GCC target("ssse3")
diff --git a/src/libsodium/crypto_generichash/blake2/ref/blake2b-ref.c b/src/libsodium/crypto_generichash/blake2/ref/blake2b-ref.c
index 0bc5b2d3..b3026b8d 100644
--- a/src/libsodium/crypto_generichash/blake2/ref/blake2b-ref.c
+++ b/src/libsodium/crypto_generichash/blake2/ref/blake2b-ref.c
@@ -405,13 +405,15 @@ int blake2b_salt_personal( uint8_t *out, const void *in, const void *key, const
 int
 blake2b_pick_best_implementation(void)
 {
-#if defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H) && defined(HAVE_SMMINTRIN_H)
+#if (defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H) && defined(HAVE_SMMINTRIN_H)) || \
+    (defined(_MSC_VER) && (defined(_M_X64) || defined(_M_AMD64) || defined(_M_IX86)))
   if (sodium_runtime_has_sse41()) {
     blake2b_compress = blake2b_compress_sse41;
     return 0;
   }
 #endif
-#if defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H)
+#if (defined(HAVE_EMMINTRIN_H) && defined(HAVE_TMMINTRIN_H)) || \
+    (defined(_MSC_VER) && (defined(_M_X64) || defined(_M_AMD64) || defined(_M_IX86)))
   if (sodium_runtime_has_ssse3()) {
     blake2b_compress = blake2b_compress_ssse3;
     return 0;